Article
Multidrug resistance proteins expression in glioma patients with epilepsy.
Journal of neuro-oncology - 1 Oct 2012
Calatozzolo Chiara, Pollo Bianca, Botturi Andrea, Dinapoli Loredana, Carosi Mariantonia, Salmaggi Andrea, Maschio Marta
Abstract excerpt
Epilepsy occurs in glioma, especially in low-grade glioma (LGG), but also in glioblastoma (GBM). In about 20 % of patients pharmacological treatment with anti-epileptic drugs (AEDs) fails. Refractory epilepsy is a multifactorial phenomenon not yet completely understood. The multidrug resistance phenotype was initially associated to P-glycoprotein (Pgp), an ATP-dependent transporter belonging to the same...
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