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Intervention-consistent causal-source recovery from covariance-response geometry reveals upstream organisation in sporadic ALS

2026-05-19

Abstract excerpt

Sporadic amyotrophic lateral sclerosis (sALS) lacks longitudinal molecular measurements, making it difficult to distinguish early disease-organising changes from downstream consequences. We present a training-free framework that extracts directional structure from static single-nucleus RNA-seq by applying discrete Hodge decomposition to gene co-expression dynamics across pseudotime-ordered donor states. The framew...

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Literature Corpus work
1fd7164c-cbcc-522a-8093-36120fd147a1
DOI
10.64898/2026.05.16.716261
Open publication

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