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Article

Nod2 deficiency impairs inflammatory and epithelial aspects of the cutaneous wound-healing response.

The Journal of pathology - 1 Jan 2013

Campbell Laura, Williams Helen, Crompton Rachel A, Cruickshank Sheena M, Hardman Matthew J

Abstract excerpt

Infection is a significant causative factor in human chronic wounds that fail to heal. Complex innate host response mechanisms have evolved whereby potentially harmful pathogens are recognized by multiple host pattern recognition receptors (PRRs), yet understanding of PRR function, or dysfunction, in the context of chronic wounds remains limited. NOD2, a cytoplasmic PRR, has been strongly implicated in chronic...

Read the complete abstract on PubMed

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Share to Dermatitis
Share to Keratinocytes
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Neutrophil Infiltration

Share to Nod2 Signaling Adaptor Protein

Share to Receptors, Interleukin-8B

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Source

Identifiers

PMID: 22951952
DOI: 10.1002/path.4095

Genes

CXCR2
NOD2
TLR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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