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Article

Simultaneous measurement of biochemical phenotypes and gene expression in single cells.

Nucleic acids research - 4 Jun 2020

Richer Amanda L, Riemondy Kent A, Hardie Lakotah, Hesselberth Jay R

Abstract excerpt

Methods to measure heterogeneity among cells are rapidly transforming our understanding of biology but are currently limited to molecular abundance measurements. We developed an approach to simultaneously measure biochemical activities and mRNA abundance in single cells to understand the heterogeneity of DNA repair activities across thousands of human lymphocytes, identifying known and novel cell-type-specific...

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Identifiers

PMID: 32286626
DOI: 10.1093/nar/gkaa240
PMCID: PMC7261187

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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