Article

Single-cell Signatures Reveal Immune Dysregulation in Nontuberculous Mycobacterial Pulmonary Disease

2026-06-01

Abstract excerpt

<title>Abstract</title> <p>Background Nontuberculous mycobacterial (NTM) pulmonary disease is characterized by chronic infection and dysregulated immunity. However, cell type-specific transcriptional changes driving disease progression remain poorly defined. Methods We performed single-cell RNA sequencing (scRNA-seq) on bronchoalveolar lavage fluid (BALF) samples from individuals with NTM pulmonary disease and...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 93bd3593-3759-57bd-8319-ec61231dc666
DOI: 10.21203/rs.3.rs-9670100/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Single-cell Signatures Reveal Immune Dysregulation in Nontuberculous Mycobacterial Pulmonary DiseaseDOI 10.21203/rs.3.rs-9670100/v1Read

Single‐Cell Transcriptomic Analysis of the Immune Response to COVID‐19 and Tuberculosis CoinfectionSemantic proximity Read

A pan-immune panorama of bacterial pneumonia revealed by a large-scale single-cell transcriptome atlasSemantic proximity Read

Single-cell transcriptome identifies FCGR3B upregulated subtype of alveolar macrophages in patients with critical COVID-19Semantic proximity Read

Single-cell transcriptomics of blood identified IFIT1 neutrophil subcluster expansion in NTM-PD patientsSemantic proximity Read

Single‐Cell Sequencing Reveals Functional Alterations in TuberculosisSemantic proximity Read

Single-cell transcriptome analysis reveals the dysregulated monocyte state associated with tuberculosis progressionSemantic proximity Read

The landscape of lung bronchoalveolar immune cells in COVID-19 revealed by single-cell RNA sequencingSemantic proximity Read

Analysis of respiratory and systemic immune responses in COVID-19 reveals mechanisms of disease pathogenesisSemantic proximity Read

Spatially resolved single-cell atlas of the lung in fatal Covid19 in an African population reveals a distinct cellular signature and an interferon gamma dominated responseSemantic proximity Read

Single-Cell Transcriptomics Reveals Depletion and Dysregulation of Mycobacterium tuberculosis –Specific Th1 and Th17 Cells Early After Acquisition of Human Immunodeficiency VirusSemantic proximity Read

Single-cell immune profiling reveals functional diversity of T cells in tuberculous pleural effusionSemantic proximity Read

Pathogen-specific host responses define distinct pneumonia endotypes in the human lungSemantic proximity Read