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Drug repurposing for Alzheimer’s disease based on transcriptional profiling of human iPSC-derived cortical neurons

6 Sept 2019

Abstract excerpt

Alzheimer's disease is a complex disorder encompassing multiple pathological features with associated genetic and molecular culprits. However, target-based therapeutic strategies have so far proved ineffective. The aim of this study is to develop a methodology harnessing the transcriptional changes associated with Alzheimer's disease to develop a high content quantitative disease phenotype that can be used to...

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PMID: 31492831
DOI: 10.1038/s41398-019-0555-x

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