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Article

Built differently or defective: can RNA exosomopathies cause ribosome heterogeneity?

Philosophical transactions of the Royal Society of London. Series B, Biological sciences - 6 Mar 2025

Bressman Zachary J, Corbett Anita H, Ghalei Homa

Abstract excerpt

The RNA exosome is an essential, evolutionarily conserved ribonuclease required for processing and degradation of key cellular RNAs. The complex maintains RNA homeostasis within every cell by ensuring the proper maturation, quality control and turnover of various RNA species including rRNAs. A growing list of diseases, collectively termed RNA exosomopathies, are caused by mutations in genes encoding structural...

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Topics

Ribosomes
Humans
Exosome Multienzyme Ribonuclease Complex
Mutation
Animals

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Identifiers

PMID: 40045779
DOI: 10.1098/rstb.2023.0382
PMCID: PMC11883433

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