Article

MET variants with activating N-lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

2023-11-05

Abstract excerpt

In hereditary papillary renal cell carcinoma (HPRCC), the hepatocyte growth factor receptor (MET) receptor tyrosine kinase (RTK) mutations recorded to date are located in the kinase domain and lead to constitutive MET activation. This contrasts with MET mutations identified in non-small cell lung cancer (NSCLC), which lead to exon 14 skipping and deletion of a regulatory domain: in this latter case, the mutated re...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1f336a79-59fe-5328-8d13-fb44239a11d0
DOI: 10.1101/2023.11.03.565283

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

MET variants with activating N-lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulationDOI 10.1101/2023.11.03.565283Read

Hereditary papillary renal carcinoma type I.Semantic proximity Read

MET in human cancer: germline and somatic mutationsSemantic proximity Read

Recording and classifying MET receptor mutations in cancers.Semantic proximity Read

MET is a potential target across all papillary renal cell carcinomas: result from a large molecular study of pRCC with CGH array and matching gene expression array.Semantic proximity Read

c-Met inhibitors with novel binding mode show activity against several hereditary papillary renal cell carcinoma-related mutations.Semantic proximity Read

MET exon 14 skipping mutation is a hepatocyte growth factor (HGF)-dependent oncogenic driver in vitro and in humanised HGF knock-in mice.Semantic proximity Read

Novel somatic mutations of the MET oncogene in human carcinoma metastases activating cell motility and invasion.Semantic proximity Read

MET∆14 promotes a ligand-dependent, AKT-driven invasive growthSemantic proximity Read

Hereditary papillary renal cell carcinomaSemantic proximity Read

Function of the c-Met receptor tyrosine kinase in carcinogenesis and associated therapeutic opportunitiesSemantic proximity Read

Two North American families with hereditary papillary renal carcinoma and identical novel mutations in the MET proto-oncogene.Semantic proximity Read

Germline MET pathogenic variants in papillary renal cell carcinomas type I: specific phenotype in French population and novel germline pathogenic variant MET c.3389T>C, p.(Leu1130Ser)Semantic proximity Read