Article
Two North American families with hereditary papillary renal carcinoma and identical novel mutations in the MET proto-oncogene.
Cancer research - 15 Apr 1998
Schmidt L, Junker K, Weirich G, Glenn G, Choyke P, Lubensky I, Zhuang Z, Jeffers M, Vande Woude G, Neumann H, Walther M, Linehan W M, Zbar B
Abstract excerpt
Hereditary papillary renal carcinoma (HPRC) is a newly recognized inherited disorder characterized by a predisposition to develop multiple bilateral papillary renal carcinomas. Individuals affected with HPRC have been shown to have germ-line mutations in the tyrosine kinase domain of the MET prot...
Topics
- 3T3 Cells
- Adult
- Aged
- Amino Acid Sequence
- Animals
- Base Sequence
- Carcinogenicity Tests
- Carcinoma, Papillary
- Female
- Humans
- Kidney Neoplasms
- Male
- Mice
- Mice, Nude
- Middle Aged