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Hereditary papillary renal cell carcinoma

14 Dec 2023

Abstract excerpt

Hereditary papillary renal cell carcinoma (HPRCC) is an autosomal dominant syndrome characterized by the occurrence of bilateral and multifocal, classic type papillary renal cell carcinomas. In the recent decades, extensive molecular studies have narrowed the molecular underpinnings of this syndrome to missense mutations in tyrosine kinase domain of MET proto-oncogene. Although MET mutations are specific to...

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PMID: 38135585
DOI: 10.1053/j.semdp.2023.12.002

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