Article
Hereditary papillary renal carcinoma type I.
Current molecular medicine - 1 Dec 2004
Dharmawardana Pathirage G, Giubellino Alessio, Bottaro Donald P
Abstract excerpt
Germline missense mutations in the tyrosine kinase domain of the hepatocyte growth factor/scatter factor (HGF/SF) receptor, c-Met, are thought to be responsible for hereditary papillary renal carcinoma (HPRC) type 1, a form of human kidney cancer. In addition to extensive linkage analysis of HPRC families localizing the HPRC type 1 gene within chromosome 7, the demonstration that individual c-Met mutations...
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