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Article

Blocking the CD47-SIRPα interaction reverses the disease phenotype in a polycythemia vera mouse model.

Leukemia - 1 Jun 2023

Lysenko Veronika, Schürch Patrick M, Tuzlak Selma, van Wijk Nicole Wildner-Verhey, Kovtonyuk Larisa V, Becher Burkhard, Manz Markus G, Kreutmair Stefanie, Theocharides Alexandre P A

Abstract excerpt

Polycythemia vera (PV) is a hematopoietic stem cell neoplasm driven by somatic mutations in JAK2, leading to increased red blood cell (RBC) production uncoupled from mechanisms that regulate physiological erythropoiesis. At steady-state, bone marrow macrophages promote erythroid maturation, whereas splenic macrophages phagocytose aged or damaged RBCs. The binding of the anti-phagocytic ("don't eat me") CD47...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37095207
DOI: 10.1038/s41375-023-01903-2
PMCID: PMC10244168

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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