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Indole-3-lactic acid suppresses colorectal cancer via metabolic reprogramming

23 May 2025

Abstract excerpt

Research indicates that abnormal gut microbiota metabolism is linked to colorectal cancer (CRC) progression, but the role of microbiota-related tryptophan metabolism disruption remains unclear. Using metagenomic sequencing and targeted Trp metabolomics, our research identified that CRC patients had abnormal indole-3-lactic acid (ILA) levels, which were related to tumor malignancy. Exogenous ILA administration...

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PMID: 40409349
DOI: 10.1080/19490976.2025.2508949

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