Article

IFNγ protects motor neurons from oxidative stress via enhanced global protein synthesis in FUS-associated Amyotrophic Lateral Sclerosis

2022-12-05

Abstract excerpt

Amyotrophic lateral sclerosis type 6 (ALS6) is a familial subtype of ALS linked to Fused in Sarcoma (FUS) gene mutation. FUS mutations lead to decreased global protein synthesis, but the mechanism that drives this has not been established. Here, we used ALS6 patient-derived induced pluripotent stem cells (hIPSCs) to study the effect of the ALS6 FUS R521H mutation on the translation machinery in motor neurons (MNs...

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Literature Corpus work: 1f138df8-a3c5-5a80-a461-6b4ad536fa23
DOI: 10.1101/2022.12.05.519150

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