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HDAC6 inhibition reverses axonal transport defects in motor neurons derived from FUS-ALS patients

5 Oct 2017

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative disorder due to selective loss of motor neurons (MNs). Mutations in the fused in sarcoma (FUS) gene can cause both juvenile and late onset ALS. We generated and characterized induced pluripotent stem cells (iPSCs) from ALS patients with different FUS mutations, as well as from healthy controls. Patient-derived MNs show typical...

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PMID: 29021520
DOI: 10.1038/s41467-017-00911-y

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