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An MLL-Independent Function of Menin Promotes Resistance to MAPK-Targeted Therapy

2026-08-26

Abstract excerpt

BRAF mutant colorectal cancer (CRC) remains difficult to treat despite the clinical use of combined BRAF and EGFR inhibition, highlighting a need to define tumour-intrinsic mechanisms that limit therapeutic response. Here, using genome-wide CRISPR-Cas9 screening in BRAF-mutant CRC cells, we identify MEN1, encoding the chromatin-associated protein Menin, as a selective determinant of sensitivity to combined encoraf...

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Literature Corpus work
1edc4ecb-6913-5f14-a366-399204537536
DOI
10.64898/2026.08.24.746076
Open publication

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An MLL-Independent Function of Menin Promotes Resistance to MAPK-Targeted TherapyDOI 10.64898/2026.08.24.746076
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