Article

PAGAN predicts digenic interactions by generalizing single-gene representations in biological networks

2026-01-29

Abstract excerpt

Digenic alterations can produce phenotypes such as synthetic lethality or digenic disease that are not observed upon individual gene perturbation, often by disrupting compensatory or redundant biological mechanisms. We hypothesized that gene pairs underlying such phenotypes share, when considered jointly, biological network properties analogous to those of essential genes or monogenic Mendelian disease genes. To t...

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Literature Corpus work: 1ed5f747-bec7-508d-8f0b-7bc3bc878223
DOI: 10.64898/2026.01.27.26344931

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