Article
Speos: an ensemble graph representation learning framework to predict core gene candidates for complex diseases.
Nature communications - 8 Nov 2023
Ratajczak Florin, Joblin Mitchell, Hildebrandt Marcel, Ringsquandl Martin, Falter-Braun Pascal, Heinig Matthias
Abstract excerpt
Understanding phenotype-to-genotype relationships is a grand challenge of 21st century biology with translational implications. The recently proposed "omnigenic" model postulates that effects of genetic variation on traits are mediated by core-genes and -proteins whose activities mechanistically influence the phenotype, whereas peripheral genes encode a regulatory network that indirectly affects phenotypes via...
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