Article

Speos: An ensemble graph representation learning framework to predict core genes for complex diseases

2023-01-13

Abstract excerpt

<h4>ABSTRACT</h4> Understanding phenotype-to-genotype relationships is a grand challenge of 21st century biology with translational implications. The recently proposed “omnigenic” model postulates that effects of genetic variation on traits are mediated by core- genes and -proteins whose activities mechanistically influence the phenotype, whereas peripheral genes encode a regulatory network that indirectly affe...

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Literature Corpus work: 4da57c99-85c4-57b2-b329-1e7a9b090cd6
DOI: 10.1101/2023.01.13.523556

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