Article
HIV-1 drug resistance. Molecular pathogenesis and laboratory monitoring.
Clinics in laboratory medicine - 1 Jun 1994
D'Aquila R T
Abstract excerpt
Molecular and clinical aspects of HIV-1 pathogenesis are described, including the turnover of the HIV-1 population in vivo, the clinical significance of resistance to HIV-1 reverse transcriptase (RT) inhibitors, and the inter-relationship between virus replication and RT inhibitor resistance. The molecular genetics of RT inhibitor resistance, including interactive effects of different RT mutations and the...
Topics
- Acquired Immunodeficiency Syndrome
- Antiviral Agents
- DNA, Viral
- Drug Resistance, Microbial
- HIV Reverse Transcriptase
- HIV-1
- Humans
- Molecular Structure
- Mutation
- RNA-Directed DNA Polymerase
- Reverse Transcriptase Inhibitors