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The AIRE G228W mutation disturbs the interaction of AIRE with its partner molecule SIRT1

2021-08-24

Abstract excerpt

The autoimmune regulator (AIRE) protein functions as a tetramer, interacting with partner proteins to form the “AIRE complex,” which relieves RNA Pol II stalling in the chromatin of medullary thymic epithelial cells (mTECs). AIRE is the primary mTEC transcriptional controller, promoting the expression of a large set of peripheral tissue antigen genes implicated in the negative selection of self-reactive thymocytes...

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Literature Corpus work
1e8056a8-7fda-5179-a1fe-47b569afc72c
DOI
10.1101/2021.08.24.457565
Open publication

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The AIRE G228W mutation disturbs the interaction of AIRE with its partner molecule SIRT1DOI 10.1101/2021.08.24.457565
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