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Article

The AIRE G228W mutation disturbs the interaction of AIRE with its partner molecule SIRT1.

Frontiers in immunology - 1 Jan 2022

Santos Jadson C, Dametto Mariangela, Masson Ana Paula, Faça Vitor M, Bonacin Rodrigo, Donadi Eduardo A, Passos Geraldo Aleixo

Abstract excerpt

The autoimmune regulator (AIRE) protein functions as a tetramer, interacting with partner proteins to form the "AIRE complex," which relieves RNA Pol II stalling in the chromatin of medullary thymic epithelial cells (mTECs). AIRE is the primary mTEC transcriptional controller, promoting the expression of a large set of peripheral tissue antigen genes implicated in the negative selection of self-reactive...

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Identifiers

PMID: 36148232
DOI: 10.3389/fimmu.2022.948419
PMCID: PMC9485725

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