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Article

Structure and site-specific recognition of histone H3 by the PHD finger of human autoimmune regulator.

Structure (London, England : 1993) - 13 May 2009

Chakravarty Suvobrata, Zeng Lei, Zhou Ming-Ming

Abstract excerpt

Human autoimmune regulator (AIRE) functions to control thymic expression of tissue-specific antigens via sequence-specific histone H3 recognition by its plant homeodomain (PHD) finger. Mutations in the AIRE PHD finger have been linked to autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED). Here we report the three-dimensional solution structure of the first PHD finger of human AIRE bound to a...

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Share to AIRE Protein
Share to Epigenesis, Genetic
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19446523
DOI: 10.1016/j.str.2009.02.017
PMCID: PMC2923636

Genes

AIRE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Structure and site-specific recognition of histone H3 by the PHD finger of human autoimmune regulator.PMID 19446523Read ↗

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