Article

Beta-Hydroxybutyrate but not NMN supplementation mimics caloric restriction reducing early mortality in <i>Daphnia</i>

2025-05-25

Abstract excerpt

NAD+ homeostasis is an important determinant of lifespan and may be a key mechanism of caloric restriction (CR) expansion of lifespan. Ketone bodies such as beta-hydroxybutyrate (BHB) that regulate NAD+ abundance and NAD+ precursors such nicotinamide mononucleotide (NMN), as are known to extend life in experimental animals and ameliorate age-related conditions in humans. We tested the hypothesis that chronic BHB a...

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Literature Corpus work: 1e7a6642-44ad-54cc-af75-5f553469a962
DOI: 10.1101/2025.05.21.655400

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