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Polygenic risk score for lower limb skeletal muscle mass and its interaction with protein and vitamin D intake in older adults.

Nutrition (Burbank, Los Angeles County, Calif.) - 1 May 2026

Liu Meiling, Park Sunmin

Abstract excerpt

OBJECTIVES: Lower limb skeletal muscle mass is essential for maintaining physical function in older adults and serves as an early indicator of sarcopenia. This study aimed to characterize the polygenic architecture of low-lower limb skeletal muscle index (low-LSMI), identify underlying biological mechanisms, and develop a polygenic risk score (PRS). METHODS: A genome-wide association study was conducted using UK...

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Identifiers

PMID: 41616609
DOI: 10.1016/j.nut.2026.113100

Genes

ADAMTSL3
CRP
CYP4F2
DPP8
FTO
IL5RA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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