Article
KRAS mutated Non-Small Lung Carcinoma: A Real World Context from the Indian subcontinent.
Cancer medicine - 1 Feb 2023
Batra Ullas, Nathany Shrinidhi, Sharma Mansi, Bp Amrith, Jose Joslia T, Singh Harkirat, Mattoo Sakshi, Mehta Anurag
Abstract excerpt
BACKGROUND: KRAS, although a common variant of occurrence (~20% of non-small-cell lung carcinoma [NSCLC]) has been untargetable, owing to the molecular structure which inherently prevents drug binding. KRAS mutations in NSCLC are associated with distinct clinical profiles including smokers and mucinous histology. KRAS G12C mutations account for ~40% KRAS altered NSCLC, but NSCLC being a geographically diverse...
Topics
- Humans
- Middle Aged
- Lung Neoplasms
- Carcinoma, Non-Small-Cell Lung
- Proto-Oncogene Proteins p21(ras)
- Retrospective Studies
- Mutation
- Carcinoma
- Lung