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The histopathological spectrum and molecular changes associated with KRAS G12C mutation in non-small cell lung carcinoma.

Pathology - 1 Oct 2024

Li Jing Jing, Wu Xiao Juan, Farzin Mahtab, Bray Victoria, Williamson Jonathan, Pal Abhijit, Yip Po Yee, Hagelamin Abeer, Ding Pei, Nindra Udit, Vinod Shalini, French Bruce, Chua Wei, Gupta Ruta, Cooper Wendy A, Wang Bin, Lee C Soon

Abstract excerpt

KRAS G12C is the most common KRAS mutation in non-small cell lung carcinoma (NSCLC), for which targeted therapy has recently been developed. From the 732 cases of NSCLC that underwent next-generation sequencing at the Department of Anatomical Pathology, Liverpool Hospital, between July 2021 and May 2023, we retrieved 83 (11%) consecutive cases of KRAS G12C mutated NSCLC, and analysed their clinical, pathological,...

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PMID: 38918148
DOI: 10.1016/j.pathol.2024.04.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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