Characterization of methylation profile in biofluid cell-free DNA and identification of differentially methylated genes for phenotypic representations in Parkinson's disease.

Abstract excerpt

BACKGROUND: The potential biomarkers for Parkinson's Disease (PD) in blood circulating cell-free DNA (cfDNA) have been infrequently explored. This study aims to identify specific methylation markers in blood cfDNA that could aid in the diagnosis of PD. METHODS: A total of twenty patients with PD and nine healthy participants were recruited for this study. Cerebrospinal fluid (CSF) and/or blood samples were...

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