Article

A Non-Canonical Effector Transcriptional Programme Characterises IFN-γ– Mediated Hyperinflammation in MIS-C

2026-08-14

Abstract excerpt

<title>Abstract</title> <p>Background Multisystem inflammatory syndrome in children (MIS-C) is a severe hyperinflammatory disorder that develops weeks after SARS-CoV-2 infection. IFN-γ is consistently implicated as a central mediator, yet the transcriptional programme and upstream signalling axis that sustain IFN-γ production in MIS-C remain poorly defined, and it is unclear whether they engage the canonical IL-...

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Literature Corpus work: 873d07e3-75d1-5ca5-8abd-e4663c21d7a7
DOI: 10.21203/rs.3.rs-10678643/v1

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