Article

Muscle spatial transcriptomic reveals heterogeneous profiles in untreated juvenile dermatomyositis and the persistence of pathological signature after remission

2025-04-16

Abstract excerpt

<h4>ABSTRACT</h4> This study aimed to investigate the spatial heterogeneity of molecular signature in the muscle of juvenile dermatomyositis (JDM) patients before and after treatment in comparison to healthy paediatric muscle tissue. Unsupervised reference-free deconvolution of spatial transcriptomics and standardized morphometry were performed in two JDM muscle biopsies with different clinical severity at diseas...

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Literature Corpus work: 1e18aacc-46af-52fb-bbb1-dba944eafc4c
DOI: 10.1101/2025.04.15.648883

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