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Article

IL-26 contributes to host defense against intracellular bacteria

1 Apr 2019

Abstract excerpt

IL-26 is an antimicrobial protein secreted by Th17 cells that has the ability to directly kill extracellular bacteria. To ascertain whether IL-26 contributes to host defense against intracellular bacteria, we studied leprosy, caused by the obligate intracellular pathogen Mycobacterium leprae, as a model. Analysis of leprosy skin lesions by gene expression profiling and immunohistology revealed that IL-26 was more...

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PMID: 30939123
DOI: 10.1172/jci99550

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