Article

Chronic striatal cholinergic interneuron excitation induces clinically-relevant dystonic behavior in mice

2023-07-21

Abstract excerpt

Dystonia is common, debilitating, often medically refractory, and difficult to diagnose. The gold standard for both clinical and mouse model dystonia evaluation is subjective assessment, ideally by expert consensus. However, this subjectivity makes translational quantification of clinically-relevant dystonia metrics across species nearly impossible. Many mouse models of genetic dystonias display abnormal striatal...

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Literature Corpus work: 6a77e0e2-8dcb-515b-8b82-98b03fac1b05
DOI: 10.1101/2023.07.19.549778

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