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Article

Impairment of bidirectional synaptic plasticity in the striatum of a mouse model of DYT1 dystonia: role of endogenous acetylcholine.

Brain : a journal of neurology - 1 Sept 2009

Martella Giuseppina, Tassone Annalisa, Sciamanna Giuseppe, Platania Paola, Cuomo Dario, Viscomi Maria Teresa, Bonsi Paola, Cacci Emanuele, Biagioni Stefano, Usiello Alessandro, Bernardi Giorgio, Sharma Nutan, Standaert David G, Pisani Antonio

Abstract excerpt

DYT1 dystonia is a severe form of inherited dystonia, characterized by involuntary twisting movements and abnormal postures. It is linked to a deletion in the dyt1 gene, resulting in a mutated form of the protein torsinA. The penetrance for dystonia is incomplete, but both clinically affected and non-manifesting carriers of the DYT1 mutation exhibit impaired motor learning and evidence of altered motor...

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Identifiers

PMID: 19641103
DOI: 10.1093/brain/awp194
PMCID: PMC2766181

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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