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Article

A three-dimensional in vitro dynamic micro-tissue model of cardiac scar formation.

Integrative biology : quantitative biosciences from nano to macro - 1 Mar 2018

Occhetta Paola, Isu Giuseppe, Lemme Marta, Conficconi Chiara, Oertle Philipp, Räz Christian, Visone Roberta, Cerino Giulia, Plodinec Marija, Rasponi Marco, Marsano Anna

Abstract excerpt

In vitro cardiac models able to mimic the fibrotic process are paramount to develop an effective anti-fibrosis therapy that can regulate fibroblast behaviour upon myocardial injury. In previously developed in vitro models, typical fibrosis features were induced by using scar-like stiffness substrates and/or potent morphogen supplementation in monolayer cultures. In our model, we aimed to mimic in vitro a...

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PMID: 29532839
DOI: 10.1039/c7ib00199a

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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