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<i>In Silico</i> Engineering of Stable siRNA Lipid Nanoparticles: Exploring the Impact of Ionizable Lipid Concentrations for Enhanced Formulation Stability

2024-09-27

Abstract excerpt

Lipid nanoparticles (LNPs) are crucial in advancing the delivery of RNA-based therapeutics within the domain of gene therapy. A comprehensive understanding of their formation and stability is critical for optimizing the clinical efficacy of LNPs. This study systematically investigates the influence of concentration variations of positive and neutral ionizable lipids - specifically, 2-[2,2-bis[(9Z,12Z)-octadeca-9,1...

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Literature Corpus work
1df388d1-c65d-5c54-b41d-fc5eb56ae6cf
DOI
10.1101/2024.09.25.614899
Open publication

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