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Article

SIRT5 regulates granulosa cell proliferation and apoptosis in polycystic ovarian syndrome via desuccinylation of GLI1

7 Jun 2025

Abstract excerpt

Polycystic ovarian syndrome (PCOS) is a major cause of infertility. Succinylation is involved in disease processes; however, its role in PCOS remains unknown. This study aimed to analyze the effect of desuccinylase SIRT5 on granulosa cell phenotype and the molecular mechanism. The levels of succinylation-related enzymes were measured using reverse transcription-quantitative polymerase chain reaction and...

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PMID: 40481676
DOI: 10.1080/09513590.2025.2515516

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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