Article

α-Synuclein impairs mitochondrial function and alters cryptochrome regulation in the substantia nigra

2026-08-21

Abstract excerpt

Dopaminergic neurons in the substantia nigra pars compacta are key targets of α-synuclein pathology and neurodegeneration in Parkinson's disease (PD). It is thought that pathological accumulation of α-synuclein significantly contributes to nigral neuronal dysfunction and ensuing neuronal demise. In this study, we further assessed this possibility and interrogated the role of α-synuclein burden in compromising neur...

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Literature Corpus work: 1d43e620-2464-5ff6-a328-3736e2ded977
DOI: 10.64898/2026.08.18.745090

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