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Article

Linezolid for Infants and Toddlers With Disseminated Tuberculosis: First Steps

14 Oct 2016

Abstract excerpt

Background. Infants and toddlers often present with disseminated and lymph node tuberculosis, in which Mycobacterium tuberculosis (Mtb) is predominantly intracellular. Linezolid, used to treat tuberculosis in adults, has not been formally studied in infants. Infants clear linezolid 5 times faster than adults and achieve lower 0- to 24-hour area under the concentration-time curves (AUC0–24). Methods. To mimic...

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PMID: 27742638
DOI: 10.1093/cid/ciw482

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