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Article

The Batten disease gene CLN3 is required for the response to oxidative stress.

Human molecular genetics - 15 May 2011

Tuxworth Richard I, Chen Haiyang, Vivancos Valerie, Carvajal Nancy, Huang Xun, Tear Guy

Abstract excerpt

Mutations in the CLN3 gene cause juvenile neuronal ceroid lipofuscinosis (JNCL or Batten disease), an early onset neurodegenerative disorder. JNCL is the most common of the NCLs, a group of disorders with infant or childhood onset that are caused by single gene mutations. The NCLs, although relat...

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Source

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Identifiers

PMID: 21372148
DOI: 10.1093/hmg/ddr088
PMCID: PMC3080613

Genes

CLN3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21372148-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Deletion of the Caenorhabditis elegans homologues of the CLN3 gene, involved in human juvenile neuronal ceroid lipofuscinosis, causes a mild progeric phenotype.Semantic proximity Read ↗

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