Article

Loss of the lysosomal protein CLN3 modifies the lipid content of the nuclear envelope leading to DNA damage and activation of YAP1 pro-apoptotic signaling

2024-06-01

Abstract excerpt

<h4>ABSTRACT</h4> Batten disease is characterized by early-onset blindness, juvenile dementia and death during the second decade of life. The most common genetic causes are mutations in the CLN3 gene encoding a lysosomal protein. There are currently no therapies targeting the progression of the disease, mostly due to the lack of knowledge about the disease mechanisms. To gain insight into the impact of CLN3 los...

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Literature Corpus work: 22e51f48-de3a-582f-bbe6-934ce4f12d1d
DOI: 10.1101/2024.05.31.596474

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