Article

Independence of HIF1a and androgen signaling pathways in prostate cancer

2019-11-26

Abstract excerpt

Androgen signaling drives prostate cancer progression and is a therapeutic target. Hypoxia/HIF1a signaling is associated with resistance to hormone therapy and a poor prognosis in patients treated with surgery or radiotherapy. It is not known whether the pathways operate in cooperation or independently. Using LNCaP cells with and without stable transfection of a HIF1a expression vector, we show that combined AR an...

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Literature Corpus work: 1d297ab0-3554-515d-9388-f28460090090
DOI: 10.1101/848424

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