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Article

Hypoxia selects for androgen independent LNCaP cells with a more malignant geno- and phenotype.

International journal of cancer - 15 Aug 2008

Butterworth Karl T, McCarthy Helen O, Devlin Andrea, Ming Louise, Robson Tracy, McKeown Stephanie R, Worthington Jenny

Abstract excerpt

Hypoxia confers resistance to common cancer therapies, however, it has also has been shown to result in genetic alterations which may allow a survival advantage and increase the tumorigenic properties of cancer cells. Additionally, it may exert a selection pressure, allowing expansion of tumor cells with a more aggressive phenotype. To further assess the role of hypoxia in malignant progression in prostate cancer...

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Source

Identifiers

PMID: 18512241
DOI: 10.1002/ijc.23418

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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