Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Androgen-Dependent Gene Expression of Prostate-Specific Antigen Is Enhanced Synergistically by Hypoxia in Human Prostate Cancer Cells

1 Apr 2007

Abstract excerpt

The androgen receptor (AR) is implicated in prostate cancer growth, progression, and angiogenesis. Hypoxia-inducible factor-1 (HIF-1), which transcriptionally regulates hypoxia-inducible angiogenic factors, is up-regulated in prostate cancers compared with adjacent normal tissues. HIF-1 may be involved in prostate cancer as well as the AR, but the involvement of HIF-1 in prostate cancer angiogenesis and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer, Hypoxia, and Metabolism
Share to Cancer, Lipids, and Metabolism
Share to Prostate Cancer Treatment and Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 17426252
DOI: 10.1158/1541-7786.mcr-06-0226

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Androgen-Dependent Gene Expression of Prostate-Specific Antigen Is Enhanced Synergistically by Hypoxia in Human Prostate Cancer CellsPMID 17426252Read ↗

Independence of HIF1a and androgen signaling pathways in prostate cancerSemantic proximity Read ↗

Hypoxia-Inducible Factor 1α and 1β Proteins Share Common Signaling Pathways in Human Prostate Cancer CellsSemantic proximity Read ↗

Hypoxia-inducible factor-1 in human breast and prostate cancerSemantic proximity Read ↗

Analysis of hypoxia-associated gene expression in prostate cancer: lysyl oxidase and glucose transporter-1 expression correlate with Gleason scoreSemantic proximity Read ↗

Hypoxia-associated p38 mitogen-activated protein kinase-mediated androgen receptor activation and increased HIF-1alpha levels contribute to emergence of an aggressive phenotype in prostate cancer.Semantic proximity Read ↗

Molecular Links Between Angiogenesis and Neuroendocrine Phenotypes in Prostate Cancer ProgressionSemantic proximity Read ↗

Genetic polymorphisms in HIF1A are associated with prostate cancer risk in a Chinese population.Semantic proximity Read ↗

Prostate specific antigen gene regulation by androgen receptorSemantic proximity Read ↗

Distinct phenotypes of human prostate cancer cells associate with different adaptation to hypoxia and pro-inflammatory gene expression.Semantic proximity Read ↗

Hypoxia selects for androgen independent LNCaP cells with a more malignant geno- and phenotype.Semantic proximity Read ↗

Knockdown of β-Catenin through shRNA cause a reversal of EMT and metastatic phenotypes induced by HIF-1α.Semantic proximity Read ↗

Chronic hypoxia promotes an aggressive phenotype in rat prostate cancer cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.