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Crystal structure of calcium bound outer membrane phospholipase A (OmpLA) from <i>Salmonella typhi</i> and <i>in silico</i> anti-microbial screening

2020-01-09

Abstract excerpt

Antimicrobial resistance is widespread in Salmonella infections that affect millions worldwide. Salmonella typhi and other Gram-negative bacterial pathogens encode an outer membrane phospholipase A (OmpLA), crucial for their membrane integrity. Further, OmpLA is implicated in pathogen internalization, haemolysis, acid tolerance, virulence and sustained infection in human hosts. OmpLA is an attractive drug target...

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Literature Corpus work
1d18b96c-cecf-5880-b5f5-375e44afc07e
DOI
10.1101/2020.01.08.898262
Open publication

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