Article
Genomic landscape of the emerging XDR Salmonella Typhi for mining druggable targets clpP, hisH, folP and gpmI and screening of novel TCM inhibitors, molecular docking and simulation analyses
2022-11-22
Abstract excerpt
Typhoid fever is transmitted by ingestion of polluted water, contaminated food, and stool of typhoid-infected individuals, mostly in developing countries with poor hygienic environments. To find novel therapeutic targets and inhibitors, We employed a subtractive genomics strategy towards Salmonella Typhi and the complete genomes of eight strains were primarily subjected to the EDGAR tool to predict the core genome...
Topics
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- Bacteriophages and microbial interactions
- Brucella: diagnosis, epidemiology, treatment
- Hepatitis B Virus Studies
- Infective Endocarditis Diagnosis and Management
- Microbial Natural Products and Biosynthesis
- Research on Leishmaniasis Studies
- Streptococcal Infections and Treatments
- vaccines and immunoinformatics approaches
Identifiers and source
- Literature Corpus work
- 69f2548e-6987-5391-bfc4-a31df12ac33f
- DOI
- 10.21203/rs.3.rs-2235299/v1
