Article
Gram-negative trimeric porins have specific LPS binding sites that are essential for porin biogenesis.
Proceedings of the National Academy of Sciences of the United States of America - 23 Aug 2016
Arunmanee Wanatchaporn, Pathania Monisha, Solovyova Alexandra S, Le Brun Anton P, Ridley Helen, Baslé Arnaud, van den Berg Bert, Lakey Jeremy H
Abstract excerpt
The outer membrane (OM) of gram-negative bacteria is an unusual asymmetric bilayer with an external monolayer of lipopolysaccharide (LPS) and an inner layer of phospholipids. The LPS layer is rigid and stabilized by divalent cation cross-links between phosphate groups on the core oligosaccharide regions. This means that the OM is robust and highly impermeable to toxins and antibiotics. During their biogenesis, OM...
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