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i In-silico i approach to identify novel potent inhibitors against GraR of i S aureus i

1 Jan 2020

Abstract excerpt

With rising antibiotic resistance at alarming rates in S. aureus, a major human pathogen, it is important to identify targets for new antimicrobial therapies. A number of two-component systems (TCS) have been implicated in S. aureus resistance to several antibiotics. The glycopeptide-resistance associated TCS, GraSR, is involved in cationic antimicrobial peptides (CAMPs) resistance through the regulation of mprF,...

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PMID: 32114436
DOI: 10.2741/4859

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