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Article

Mutations at site 207 of influenza a virus NS1 protein switch its function in regulating RIG-I-like receptors mediated antiviral responses.

Antiviral research - 1 Jul 2023

Wang Xingbo, Lin Lulu, Chen Zhen, Si Wei, Yan Yan, Dong Weiren, Jin Yulan, Huang Yu, Zhou Jiyong

Abstract excerpt

RIG-I-like receptors (RLRs), retinoic acid inducible gene I (RIG-I) and melanoma differentiation-associated protein 5 (MDA5), are pattern recognition receptors through which cells initially sense pathogenic RNA and trigger interferon (IFN) signaling. Herein, we report that interferon induced protein 35 (IFI35) activates the ring finger protein 125 (RNF125)-UbcH5c-dependent degradation of RLRs and represses the...

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Source

Identifiers

PMID: 37230297
DOI: 10.1016/j.antiviral.2023.105641

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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