Article

Mitochondrial dysfunction compromises ciliary homeostasis in astrocytes

2021-08-27

Abstract excerpt

Astrocytes, often considered as secondary responders to neurodegenerative processes, are emerging as primary drivers of brain disease. The underlying pathogenic mechanisms are, however, insufficiently understood. Here we show that pathogenesis of mitochondrial spongiotic encephalopathy, a severe manifestation of mitochondrial brain diseases, involves abnormal maintenance of the astrocytic primary cilium, a major s...

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Literature Corpus work: 1cebad96-b419-58b1-b01a-62ecda13f3bc
DOI: 10.1101/2021.08.24.457472

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