Article

Endothelin-1 upregulates activin receptor-like kinase-1 expression via Gi/RhoA/Sp-1/Rho kinase pathways at transcriptional and post-transcriptional levels in human pulmonary arterial endothelial cells

2020-05-07

Abstract excerpt

<title>Abstract</title> BackgroundsPulmonary arterial hypertension (PAH) is a disease with poor prognosis that is characterized by pulmonary vasoconstriction and organic stenosis due to abnormal proliferation of pulmonary vascular cells. It has been demonstrated that endothelin (ET)-1 induces pulmonary vasoconstriction through activation of RhoA. Moreover, we previously demonstrated that G<italic>i</italic>, a...

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Literature Corpus work: 1ce4fda5-6777-589a-8deb-87b0fa900ecd
DOI: 10.21203/rs.3.rs-25396/v1

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Endothelin-1 upregulates activin receptor-like kinase-1 expression via Gi/RhoA/Sp-1/Rho kinase pathways at transcriptional and post-transcriptional levels in human pulmonary arterial endothelial cellsDOI 10.21203/rs.3.rs-25396/v1Read

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